Page 24 of 35 FirstFirst ... 14 22 23 24 25 26 34 ... LastLast
Results 346 to 360 of 524

Thread: WTF :2019-nCoV NovaCoronaVirus Thread

  1. #346
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,400

    Default

    The US got off to a good start because of Operation Warp Speed. The govt shredded a bunch of red tape, directed massive emergency funding to the pharma companies, then brought in the Army to help with logistics and security.

    Then they made a major bureaucratic change; instead of producing any successful vaccine candidates after approval they started production of all candidates during their Phase 3 trials. On approval they immediately started distribution.

    Johnson & Johnson suspended in the US because of 6 patients in 6.8 million presenting with a cerebral venous sinus thrombosis, the same issue as AstraZeneca. This ~1 in 1 million prevalence compared to ~5 in 1 million for the general population seems minor, but they need to check it out.

    Moderna 6 months after injection #2

    90% effective at preventing illness
    95% effective at preventing severe illness

    A new Moderna formulation is cooking with updates for new strains, but it's been pretty effective against those. Abundance of caution.

    In MI we're jabbing arms with Moderna and Pfizer as fast as they can ship. We started with seniors - the most vulnerable, medical personnel, and first responders. Now most of our cases are younger folks, and many "new" deaths are a result of record reviews.
    Last edited by Dr Mordrid; 15th April 2021 at 13:41.
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  2. #347
    Crabby Smurf Umfriend's Avatar
    Join Date
    Mar 2001
    Location
    Netherlands
    Posts
    6,992

    Default

    I am not sure about this but I think the EU has two main issues:
    1. The EU, like the US, pre-ordered vaccines (so that is not where Warp Speed is unique) but our logistics are sub-optimal.
    2. The EU, although it ordered BioNTech/Moderna, had anticipated wide use of Astra and Janssen. Perhaps just a bit unlucky.

    But I think currently the real issue is that out of some precautionary principle, we refuse to use Astra and Janssen, even if the odds of mishaps are small and the societal cost of delaying are worse.
    Join MURCs Distributed Computing effort for Rosetta@Home and help fight Alzheimers, Cancer, Mad Cow disease and rising oil prices.
    [...]the pervading principle and abiding test of good breeding is the requirement of a substantial and patent waste of time. - Veblen

  3. #348
    Moderator dZeus's Avatar
    Join Date
    Aug 2000
    Location
    over there
    Posts
    4,610

    Default

    Quote Originally Posted by Umfriend View Post
    I am not sure about this but I think the EU has two main issues:
    1. The EU, like the US, pre-ordered vaccines (so that is not where Warp Speed is unique) but our logistics are sub-optimal.
    2. The EU, although it ordered BioNTech/Moderna, had anticipated wide use of Astra and Janssen. Perhaps just a bit unlucky.

    But I think currently the real issue is that out of some precautionary principle, we refuse to use Astra and Janssen, even if the odds of mishaps are small and the societal cost of delaying are worse.
    What I find baffling is that the risk of getting a blood clotting disorder from the Johnson&Johnson and AstraZeneca vaccines does not seem to be larger than the risk of getting complications from getting infected with covid, not even taking into account the society-wide protective effect of reaching herd immunity thanks to vaccinating earlier (rather than later with mRNA-based vaccines). This is why I think Britain is taking the right approach... the benefits outweigh the risks and they clearly communicate this (rather than giving mixed messaging that undermines the vaccination campaign, which is happening all over the EU and to some degree in the US).

    If the principle of autonomy over getting vaccinated with the J&J or AZ vaccine is so important, you can give people the choice to take this decision for themselves. But stopping vaccination altogether seems an incredulous choice imo...
    Last edited by dZeus; 16th April 2021 at 03:48.

  4. #349
    Crabby Smurf Umfriend's Avatar
    Join Date
    Mar 2001
    Location
    Netherlands
    Posts
    6,992

    Default

    What dZ said.
    Join MURCs Distributed Computing effort for Rosetta@Home and help fight Alzheimers, Cancer, Mad Cow disease and rising oil prices.
    [...]the pervading principle and abiding test of good breeding is the requirement of a substantial and patent waste of time. - Veblen

  5. #350
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,400

    Default

    I also agree.

    The apparent risk of CVST "from the vaccine" is not only lower than the CoVid-19 risk but it appears to be lower than the background rate of CVST.

    C'mon bureaucrats, get a friggin' grip already...
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  6. #351
    Crabby Smurf Umfriend's Avatar
    Join Date
    Mar 2001
    Location
    Netherlands
    Posts
    6,992

    Default

    Although, as I understand it, the number of cases where they experienced CVST + low platelets is higher than expected in a control group. Regardless, the numbers so far indicate we should use both vaccines.

    With us, one of the problems appears to be that we now have a plan with respect to which groups go when and that does not work if vaccination is optional (of course, it is optional now as well but if you decline you go the back-end of the list to try again). But I fail to see why you couldn't have a group-sequenced plan for BioNTech/Moderna (the latter of which we get very little sofar) and do the others to whomever wants it on a lottery basis. Sure, you want to do certain groups first but now we're not doing them at all...
    Join MURCs Distributed Computing effort for Rosetta@Home and help fight Alzheimers, Cancer, Mad Cow disease and rising oil prices.
    [...]the pervading principle and abiding test of good breeding is the requirement of a substantial and patent waste of time. - Veblen

  7. #352
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,400

    Default

    Michigan now has enough Moderna & Pfizer/BioNTech that adults can be vaccinated on request; hospitals, clinics, pharmacy stores, pharmacy outreachs to senior apartments or programs, city or county run vaccination sites, etc.

    MI population: 9.9 million

    % received at least 1 dose,

    65+: 71.6%
    Total 16+: 43%

    Our problem is unvaccinated people under 40 who think they're immortal, especially 20-somethings (22.7%).

    https://www.nbcnews.com/health/healt...eport-n1264881

    Covid vaccine appears to be safe during pregnancy, large CDC report shows

    One of the largest reports on*Covid-19 vaccination in pregnancy bolsters evidence that it is safe although the authors say more comprehensive research is needed.

    The preliminary results are based on reports from over 35,000 U.S. women who received either the Moderna or*Pfizer shots while pregnant. Their rates of miscarriage, premature births and other complications were comparable to those observed in published reports on pregnant women before the pandemic.
    >
    Last edited by Dr Mordrid; 22nd April 2021 at 06:12.
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  8. #353
    Super MURCer UtwigMU's Avatar
    Join Date
    Jul 2002
    Location
    Sin City
    Posts
    5,357

    Default

    The story of coworker who had breakdown last year continues. He is working 4h, 4h sick leave paid by state. I've found out one of his two early teens daughter has cancer and has spent time in hospital. His wife has a chronic illness and also had covid. And to make matters worse recently they discovered a tumor on his kidney, don't know whether it's malign yet. Since they live in small apartment he and wife hide illnesses from daughters and it's hard to keep communication down.

    Now I understand sentence spoken a year ago: Take care of my wife and daughters for me.

    We collected cash (in midsize company even if everyone chips in a little it's something) that coworker will secretly give to his wife. He is too proud to take money. Management is also helping him with bonuses.

    He is a really nice guy full of heart. Shit usually happens to good people.

  9. #354
    Crabby Smurf Umfriend's Avatar
    Join Date
    Mar 2001
    Location
    Netherlands
    Posts
    6,992

    Default

    @Doc: Jealous
    @Utwig: Rough... Nice that his colleagues try to help
    Join MURCs Distributed Computing effort for Rosetta@Home and help fight Alzheimers, Cancer, Mad Cow disease and rising oil prices.
    [...]the pervading principle and abiding test of good breeding is the requirement of a substantial and patent waste of time. - Veblen

  10. #355
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,400

    Default

    Friday an NBC reporter said the White House is "fed up" with J&J's production problems.

    Before this were reports their Emergent supplier had been closed for filthy conditions. Millions of doses also tossed due to contamination.

    https://www.moneycontrol.com/news/co...99011.html/amp
    Last edited by Dr Mordrid; 25th April 2021 at 02:32.
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  11. #356
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,400

    Default

    Moderna update;

    targeting 3 billion CoVid-19 doses

    Vaccines in/entering trials,

    HIV x2
    Influenza
    Cytomegalovirus
    Respiratory syncytial virus
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  12. #357
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,400

    Default

    Michigan is now offering at-home vaccination for shut-ins.

    Soon the home healthcare providers will get allocations for their patients.

    7.22 million doses given.
    3.25 million fully vaccinated

    As before, most of our vaccinations are Moderna and Pfizer-BioNTech.
    Last edited by Dr Mordrid; 2nd May 2021 at 04:18.
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  13. #358
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,400

    Default

    Michigan: no masks outside for youth sports, small gatherings like wedding & graduation parties, etc.

    Moderna is saying 3 month storage in standard refrigerators, and 7 months at -4°F/-20°C. This will be a boon for shipping & vaccinating remote areas.

    [https://www.cnbc.com/2021/04/29/mode...4%20Fahrenheit.
    Last edited by Dr Mordrid; 4th May 2021 at 23:33.
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  14. #359
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,400

    Default

    Michigan now has 51% which have received at least 1 vaccination dose (vast majority here are Moderna and Pfizer-BioNTech).

    Even a single dose of either mRNA is delivering immunity roughly equal to J&J and other single-dose adenovirus-based vaccines; 60-70%.

    mRNA vaccines are ~94% for both doses.

    Unlike BioNTech, which partnered with the US's Pfizer, CureVac has no US partner. This has led to them not having unrestricted access to US-made nucleotides for producing their mRNA vaccine.

    This access restriction was brought on by Pres. Biden implementing the Defense Production Act in March.

    https://www.lawfareblog.com/understa...production-act
    Last edited by Dr Mordrid; 5th May 2021 at 03:46.
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  15. #360
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,400

    Default

    Updated Moderna...

    https://www.cnbc.com/2021/05/25/covi...k-in-june.html

    Moderna says its Covid vaccine is 100% effective in teens, plans to seek FDA OK in early June

    KEY POINTS

    • Moderna said Tuesday its Covid-19 vaccine was 100% effective in a study of adolescents ages 12 to 17.

    • The company said it plans to ask the FDA to expand the emergency use of its Covid vaccine for teens early next month.

    • It is the second vaccine behind Pfizer’s to demonstrate high efficacy in younger age groups.
    >
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

Thread Information

Users Browsing this Thread

There are currently 2 users browsing this thread. (0 members and 2 guests)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •