Page 14 of 14 FirstFirst ... 4 12 13 14
Results 196 to 208 of 208

Thread: WTF :2019-nCoV NovaCoronaVirus Thread

  1. #196
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,108

    Default

    Wisconsin's State Supreme Court has ruled their governor's shelter in place orders unconstitutional.

    Michigan governor's shelter in place orders are being challenged in court as well.
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  2. #197
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,108

    Default

    Conference call today;

    the Moderna* mRNA-1273 vaccine is generating recovery level antibodies in 100% of participants and may go into wide Phase 3 trials in July, with doses between 25ug and 100ug.

    They applied for Phase 2 about 2 weeks ago.

    * Boston, MA
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  3. #198
    Serial Murcerer ZokesPro's Avatar
    Join Date
    Sep 2000
    Location
    Quarantine
    Posts
    14,574

    Default

    Quote Originally Posted by Dr Mordrid View Post
    Conference call today;

    the Moderna* mRNA-1273 vaccine is generating recovery level antibodies in 100% of participants and may go into wide Phase 3 trials in July, with doses between 25ug and 100ug.

    They applied for Phase 2 about 2 weeks ago.

    * Boston, MA
    Interesting!

    And then what? What if phase 3 bring similar results?
    This is the way.

  4. #199
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,108

    Default

    Quote Originally Posted by ZokesPro View Post
    Interesting!

    And then what? What if phase 3 bring similar results?
    FDA Phase 3 usually involves 3,000± people with the condition a drug is to treat. This phase can take a few years.

    <speculation alert>

    Giving it to an uninfected person then exposing them presents ethical issues. This may be tested as a treatment for early positive patients

    Most drugs could spend 2-3 years at Phase 3, but at the call they reported it's well tolerated. IMO, with good results they could do a Fast-Track humanitarian release as early as January.
    Last edited by Dr Mordrid; 18th May 2020 at 18:29.
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  5. #200
    Crabby Smurf Umfriend's Avatar
    Join Date
    Mar 2001
    Location
    Netherlands
    Posts
    6,993

    Default

    Quote Originally Posted by Dr Mordrid View Post
    Giving it to an uninfected person then exposing them presents ethical issues. This may be tested as a treatment for early positive patients

    Most drugs could spend 2-3 years at Phase 3, but at the call they reported it's well tolerated. IMO, with good results they could do a Fast-Track humanitarian release as early as January.
    I can see that. But with the prevalence of Covid, the mild progression expected for <50yo and assuming good disclosure I could see people volunteering. Even if about 50% of the volunteers will actually get Covid-19.

    Also, I don;t understand how a vaccine can be tested on early positives. Isn't the body already working to find out how to create antibodies? It sounds more like a test that would be appropriate for a cure, not a vaccine. Just wondering and knowing little about this.
    Join MURCs Distributed Computing effort for Rosetta@Home and help fight Alzheimers, Cancer, Mad Cow disease and rising oil prices.
    [...]the pervading principle and abiding test of good breeding is the requirement of a substantial and patent waste of time. - Veblen

  6. #201
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,108

    Default

    Quote Originally Posted by Umfriend View Post
    I can see that. But with the prevalence of Covid, the mild progression expected for <50yo and assuming good disclosure I could see people volunteering. Even if about 50% of the volunteers will actually get Covid-19.

    Also, I don;t understand how a vaccine can be tested on early positives. Isn't the body already working to find out how to create antibodies? It sounds more like a test that would be appropriate for a cure, not a vaccine. Just wondering and knowing little about this.
    mRNA vaccines are new, and work different. Think in terms of a Barrett sniper rifle rather than a shotgun.

    Most vaccines work by using a part of the bacteria or virus to stimulate the immune system into producing antibodies, a complex process. Some of these will work, some not so much. The hope is enough of the working antibodies will be made to fight off the disease.

    In mRNA vaccines you program messenger RNA, think if it as a boot tape, for making only the molecule you want. Once cells are booted up to run the mRNA it forces the cell's machinery to mass produce that specific molecule. The molecule of choice is the spike the virus uses to attach to our cells. The immune system sees this masive collection of spike proteins and marshalls troops for battle, creating antibodies and (hopefully) immunity..



    Because of this mass production some mRNA vaccines can be used as either a vaccine or as a treatment.

    mRNA vaccines have been created for Zika, rabies, and have the potential to create a family of cancer vaccines. Could be a Really*Big*Deal.
    Last edited by Dr Mordrid; 19th May 2020 at 13:50.
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  7. #202
    Crabby Smurf Umfriend's Avatar
    Join Date
    Mar 2001
    Location
    Netherlands
    Posts
    6,993

    Default

    Thanks for that. What I don't understand is this: If you are infected with the Covid-19 virus, you already have virii with the spike that your immune system must learn to attach to / create antibodies for. So how then does a treatment that *simply* introduces that same spike to your body help?
    Join MURCs Distributed Computing effort for Rosetta@Home and help fight Alzheimers, Cancer, Mad Cow disease and rising oil prices.
    [...]the pervading principle and abiding test of good breeding is the requirement of a substantial and patent waste of time. - Veblen

  8. #203
    Super MURCer UtwigMU's Avatar
    Join Date
    Jul 2002
    Location
    Sin City
    Posts
    5,164

    Default

    The problem with Covid as I read is that if it doesn't enter lungs the disease passes without symptoms or with mild. In slovenia 3% of national sample of 1300 people had had Covid while they had some or no symptoms.

    If it enters lung the immune system reacts and attacks virii as well as lung tissue where they are produced. This leads to low oxygen saturation lung damage and can lead to pneumonia. This is why most have no to mild symptoms while some (=<1%) need to be hospitalized.

  9. #204
    Serial Murcerer ZokesPro's Avatar
    Join Date
    Sep 2000
    Location
    Quarantine
    Posts
    14,574

    Default

    You know the govt message has gotten through when you hear your nine year playing with star wars lego says "I'm going to attack you at 2m distance!", lol.
    Last edited by ZokesPro; 19th May 2020 at 04:33.
    This is the way.

  10. #205
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,108

    Default

    Quote Originally Posted by Umfriend View Post
    Thanks for that. What I don't understand is this: If you are infected with the Covid-19 virus, you already have virii with the spike that your immune system must learn to attach to / create antibodies for. So how then does a treatment that *simply* introduces that same spike to your body help?
    Most often there aren't enough CoVid-19 virii to overwhelm a healthy immune system, there's excess capacity. Here using the vaccine shortly after Infection can further tip the odds.

    When the patient has a suppressed immune system from age or cosorbidities; diabetes, overweight, cardiovascular disease, etc. there's diminished capacity to mount the battle. Next, inflammation turns the immune system itself against its owner - it becomes an autoimmune condition. This is commonly known as "cytokine storm syndrome" and it's often lethal. Here giving the vaccine early, well before the storm, may help head it off.

    Age and comorbidities are why we've been seeing 50%+ of the deaths occurring in nursing & veterans homes, senior apartments, assisted living centers, etc. Staffers at these centers are often asymptomatic carriers, up to 75% testing positive at Detroit senior centers. Also at high risk are seniors who live with extended families, who can also be carriers.

    Then we have idiots like NY Governor Cuomo who sent recovering CoVid-19 patients back to the senior homes. Dumb.

    https://www.wsj.com/articles/new-yor...or-11589470773
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  11. #206
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,108

    Default

    https://arstechnica.com/science/2020...d-by-new-data/

    Feared “reactivation” of COVID-19 infections disputed by new data

    "Re-positive" cases didn't spread disease or shed


    People who recover from COVID-19 but test positive for the virus again days or weeks later are not shedding viral particles and are not infectious, according to data released Tuesday by the Korea Centers for Disease Control and Prevention.

    The so-called “re-positive” cases have raised fears that an infection with the new coronavirus, SARS-CoV-2, could “reactivate” in recovered patients or that recovering from the infection may fail to produce even short-lived immunity, allowing patients to immediately become re-infected if they are exposed.

    The new data from Korea should ease those concerns.

    >
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  12. #207
    Moderator Dr Mordrid's Avatar
    Join Date
    Apr 2001
    Location
    Westland, MI
    Posts
    26,108

    Default

    NY has published their nursing home deaths (and suspected) numbers. They're high, no doubt because of NY Gov. Cuomo (D) sending 4,500 infected elderly patients into nursing homes like so many Typhoid Marys.

    Several other states have had a similar policy, but reversed them. Not so Michigan Governor Gretchen Whitmer (D), triggering calls for an investigation. Seemingly stuck on stupid.

    https://www.detroitnews.com/story/ne...rs/5217735002/

    Scathing Associated Press story on NY's policy,

    https://apnews.com/5ebc0ad45b73a899efa81f098330204c

    A short taste,

    Whatever the full number, nursing home administrators, residents’ advocates and relatives say it has added up to a big and indefensible problem for facilities that even Gov. Andrew Cuomo - the main proponent of the policy - called “the optimum feeding ground for this virus.”
    Total nursing home & adult care deaths by AP's count: 5,800 - more than in any other state.

    NY State May 24 report

    https://www.health.ny.gov/statistics...g_home_acf.pdf
    Dr. Mordrid
    ----------------------------
    An elephant is a mouse built to government specifications.

    I carry a gun because I can't throw a rock 1,250 fps

  13. #208
    Super MURCer Paddy's Avatar
    Join Date
    Mar 2000
    Location
    Western Australia
    Posts
    6,275

    Default

    We've turned ourselves into the country of 'Westralia' [Western Australia]. Hard boarders across state lines and only just allowing regional travel.
    That being said, we only had two active cases a few days ago and nine deaths in total. Number of active cases just increased to about twelve when we repatriated a flight and let a ship dock yesterday.

    The whole state went on immediate lockdown so we're stuck in the situation that we are unable to let anyone in as the entire populous lacks exposure/immunity...
    The Welsh support two teams when it comes to rugby. Wales of course, and anyone else playing England

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •