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  • What a gas!

    I have often thought that the common or garden fart was misnamed as being the result of enteric fermentation, when the result was exitic. However, this explains all!

    What a Gas
    by Jeffrey Kluger

    There are worse places to be than Dr. Michael Levitt's waiting room.
    Chernobyl, for instance. Or Love Canal.

    It's not that there's anything wrong with Levitt's facilities
    themselves, you understand. Indeed, as doctor's offices go, they're
    better than most. There are no millennia-old copies of Travel & Leisure
    on the coffee table (A Weekend in Pangaea!), no sour balls from the
    mid-1950s in the receptionist's candy dish, no relentless Muzak
    repetitions of The Girl From Ipanema. No, the problem with Dr. Levitt's
    waiting room is Dr. Levitt's patients.

    Michael Levitt is a gastroen-terologist working at the Veterans Affairs
    Medical Center in Minneapolis. The term gastroenterology, of course,
    refers to the branch of medicine that treats ailments of the stomach and
    bowels and comes from the Greek gaster, for belly, and enterology, for
    someone who really ought to wash his hands before making you a sandwich.
    For a medical specialty high in heroism and low in glamour, you can't do
    much better than gastroenterology, but in Levitt's practice the stakes
    have been raised. For the past 15 years, Levitt has been roundly
    recognized as one of the world's leading authorities on the science of
    flatulence.

    Flatulence is the means by which the body rids the colon of unwanted
    gases, the intestines of unwanted pressure, and crowded theater rows of
    unwanted strangers. Its familiarity notwithstanding, it has generally
    ranked near the bottom of most people's lists of Impressive Things the
    Body Can Do--just a notch above the ability to flatten Coors cans
    against our foreheads. Despite the low esteem in which nature's joy
    buzzer has been held, however, a handful of researchers have made it the
    chief object of their study. What, they have asked themselves, can it
    tell us about the functioning of the body? How, they have challenged one
    another, can it be alleviated when it becomes excessive? Why, their
    families have asked them, couldn't they at least have considered a nice
    podiatry practice? Levitt is one of the rare scientists who have been
    willing to tackle these questions, and after 19 years in the flatus
    game, he does not regret his choice.

    An enormous amount of lore has grown up around the phenomenon of
    flatulence, he says, much of it untrue. Debunking these myths and
    uncovering the truth is like investigating any poorly understood area of
    medicine. The answers are all there--if you're willing to go after them.

    Levitt came by his interest in eruptive science in a somewhat dramatic
    way. In 1976 a patient approached him with what Levitt later decorously
    described in a New England Journal of Medicine paper as a five- year
    history of passing excessive flatus. The demure phrasing in Levitt's
    writing did nothing to capture the problems his patient faced. Since
    1971, the prudently unnamed 28-year-old male confessed, he had been
    passing intestinal gas far more than he ever had before in his life, and
    certainly more than any of his understandably put-upon friends and
    family members. For the previous two years, he had been keeping a
    scrupulous record of his personal greenhouse emissions, and when he
    revealed these so-called flatugraphic recordings to Levitt, the doctor
    was taken aback. On an average day the patient recorded 34 episodes of
    flatulence, with some days cresting into the low 40s. Levitt did not
    have any data on how this compared with the output of the ordinary
    person, but even in a globally warmed, ozone-shredded,
    chlorofluorocarboned world, this sounded bad. Before his unhappy patient
    detonated at a mooring mast in Lakehurst, New Jersey, Levitt decided to
    take his case.

    In treating a man complaining of flatulence, there are many things a
    doctor must consider--not the least being that the patient is a man.
    >From toddlerhood to dotage, there are few skills more highly prized by
    the average male than a facility with flatulence. Why men should seem
    more open about their gastric volatility than women is a mystery, but
    from a sex whose inventiveness gave the world the noogie and the wedgie,
    a fascination with all things intestinal should not come as a surprise.
    While most men do what they can to curb this natural impulse, limiting
    themselves to such flatus surrogates as whoopee cushions and fireworks,
    an affinity for flatulence remains.

    To study a problem of extraordinary flatus, Levitt needed data on what
    ordinary flatus is. Recruiting seven highly cooperative volunteers, he
    requested that they spend at least a week keeping flatugraphic logs of
    their own, recording how frequently they stirred intestinally and when
    these events occurred. While taking the time to note such events would
    not make for an especially social week, it would make for a
    scientifically enlightening one, providing Levitt with what was almost
    certainly science's first flatulence control group. When the results
    were in, it was clear that control was just what his seven volunteers
    did have and what his troubled patient didn't.

    In the group I chose, Levitt says, the mean flatus frequency turned out
    to be 13.6 episodes per day, with no statistically significant
    differences attributable to age, gender, or other discernible variables.
    The upper limit for even the most gaseous of these subjects was less
    than 20. In all cases the daily output was considerably lower than my
    patient's 34, indicating that his problem was quite real.

    More disturbing than the frequency of flatus from the afflicted man was
    the quantity of effluence produced by each event. It's well known that a
    flatulent episode can range from a barely detectable rumble to a
    propulsive burst sufficient to attain low Earth orbit, depending on
    general health and recent visits to all-you-can-eat salad bars. With the
    help of internally worn rectal tubes and 100-milliliter collection
    syringes, an earlier study had determined just what the standard output
    of all these eruptions is.

    The average person appears to release between 500 and 2,000 milliliters
    of gas per day rectally, Levitt says, with the average volume of what
    passes at once varying between 35 and 90 milliliters. The young man I
    was treating released an average of 5,520 milliliters per day, or 162
    milliliters per event.

    By any measure, it was clear that Levitt had discovered the Joltin' Joe
    of digestive distress, but before consigning the unfortunate man to a
    private wing in gastroenterology's Hall of Fame, Levitt knew he'd have
    to investigate further. The next step, he decided, was to study not just
    the quantity of the patient's gaseous output but its makeup. Given the
    power of intestinal exhaust to turn heads, clear rooms, and in extreme
    cases fell whole swaths of old-growth forest in the Pacific Northwest,
    this least fragrant vapor would seem to be made of only the most pungent
    stuff. Yet according to analyses Levitt--and later others--conducted on
    captured flatulence, intestinal gas can be surprisingly benign.

    When you analyze rectal gas, Levitt says, you find that it is about 99
    percent carbon dioxide, hydrogen, nitrogen, oxygen, and methane. Most of
    these gases are either swallowed inadvertently when food is eaten or
    released from the food as it is digested. What makes this remarkable to
    most people is not just that these gases are so common but that they are
    also utterly odorless.

    For flatus to attain its singular bouquet, it must rely on the remaining
    1 percent of the gas that makes it up--a percent composed of very
    different stuff, which comes from a very different source. Like all
    complex organisms, the human body is home to millions of microorganisms
    that live in our hair, pores, and even our internal organs. The part of
    the body that is apparently zoned for the most residential
    development--at least by house-hunting one-celled organisms without much
    of an eye for resale values--is the digestive tract. Among the better
    known microbes that receive their E-mail and E! channel in your
    intestines is the prolific E. coli. Among the lesser known are
    Klebsiella and Clostridium. All these organisms live for the most part
    in the colon, where they attack and consume undigested food and in turn
    generate their own waste products. In the case of microorganisms, waste
    usually means gas, and in the case of these microorganisms, that gas can
    be pretty ripe stuff--usually molecules containing sulfur, such as
    dimethyl sulfide and methanethiol. When these waste products build up to
    a sufficient level, they are released with the rest of the gas in the
    bowels, announcing their presence--and too often yours--to the world.

    The odoriferous gases present in flatus are present in extremely small
    concentrations, Levitt says. It is a testament both to the pungency of
    the gases and to the sensitivity of the nose that we can detect them so
    readily.

    Of course, not all episodes of flatulence carry an olfactory price tag.
    Some people, it seems, can release all the intestinal gas they want with
    no one the wiser, while other people seem to be unable to enter a room
    without first having to file an environmental impact statement. While
    it's tempting to conclude that individual quirks of individual
    metabolisms account for these differences, the answer usually has less
    to do with our bodies than with what we put into them--particularly when
    what we put into them are carbohydrates.

    ...
    Brian (the devil incarnate)

  • #2
    ...Nutritionists have long known that while there are many kinds of
    carbohydrates present in food, Levitt says, not all of them are
    digestible. Generally it is only the simplest carbohydrates, made up of
    the simplest sugars, that we're able to process. Some complex
    carbohydrates-- those made up of three or four sugar molecules--can't be
    broken down by normal metabolism. When these get into the digestive
    tract, they are simply passed along to the colon, where the intestinal
    flora get hold of them.

    Among the foods with the fewest complex carbohydrates and thus the
    fewest flatulent consequences are meat, fish, grapes, berries, potato
    chips, nuts, and eggs--the so-called normoflatugenic foods. Further up
    the gaseousness scale are pastries, potatoes, citrus fruits, apples, and
    breads, all of which contain some complex sugars, and thus some
    potential for flatulent fallout. At the top of the explosiveness list
    are the Fat Man and Little Boy of our diets--those foods that are
    practically nothing but complex sugars. Among these most eruptive
    edibles are beans, carrots, raisins, bananas, onions, milk, and milk
    products.

    When Levitt began treating his grievously gassy patient, it was these
    well-nigh radioactive consumables that first drew his attention. In his
    initial journal paper, as well as in a subsequent paper entitled
    Follow-up of a Flatulent Patient (itself later followed up by Flatulent
    Patient: The Musical!), Levitt described the painstaking process by
    which the patient altered his diet to determine which foods were
    responsible for his distress. During the first three weeks of the
    patient's treatment regimen, Levitt restricted him to the
    normoflatugenic foods and got immediate results: the incidence of flatus
    fell from 34 bursts per day to fewer than 17--well within the normal
    range. After this trial period, Levitt and his patient tested the
    possibility that the young man's gas- producing proclivity had
    diminished by adding a full quart of milk to his diet.

    While residents of Minneapolis do not refer to The Day Michael Levitt
    Gave His Flatulent Patient Milk with the same post-traumatic numbness
    exhibited by, say, survivors of Mount Pinatubo, the event could not have
    gone wholly unnoticed. In the 24 hours that followed the milk ingestion,
    the patient reached something close to critical gaseous mass, recording
    fully 90 episodes of flatus in his flatugraphic diary, including one
    especially productive three-hour period in which he experienced nearly
    60 intestinal utterances. The cause and effect between input and output
    was so immediate and so direct that Levitt knew he had found his
    smoking, uh, gun.

    It turned out, he says, that this patient was lactose intolerant.
    Lacking the enzyme to digest the carbohydrates in milk, he simply passed
    them on to his colon, where the bacteria digested them for him. In many
    lactose-intolerant patients, milk ingestion can lead to gas. In this
    patient the intolerance was severe, so the gas problem was, too.

    The solution to the patient's gaseousness was simple, involving nothing
    more than maintaining the low-flatulence diet, and on those occasions
    when milk was ingested, consuming it only with an accompanying dose of
    lactase, an enzyme that aids in milk metabolism. In the years since,
    Levitt has lost contact with the now middle-aged man, and with the
    exception of a few false alarms--California's 1994 Northridge quake, for
    example--all has been quiet on at least that flatulence front. But even
    though his patient's mystery has been solved, Levitt himself has hardly
    been lying down on the job, using the last two decades to expand
    science's flatus horizons even further.

    Among the greatest challenges he and the rest of medicine's flatulence
    strike force now face is determining whether there is a way to curb
    intestinal gas without appreciably restricting a patient's diet. The
    solution may well involve enlisting the aid of some of the very
    microorganisms that stir things up in the first place. The
    Methanobacterium smithii bacterium, Levitt has learned, is a bit of a
    microbial specialist, producing not the whole range of gases that make
    up flatulence but just methane, a gas molecule made up of four hydrogen
    atoms and one carbon atom. As M. smithii manufactures its gas of choice,
    it reduces the overall volume of gas surrounding it by condensing four
    stray molecules of hydrogen and one of carbon dioxide into a single
    molecule of methane and two waters (which are absorbed by the colon),
    thus lowering the pressure in the bowels in the process. The problem, as
    Levitt has learned, is that M. smithii is one of the least common of all
    bowel bacteria, far outnumbered by E. coli and its less fragrant ilk.
    Short of running a less than appealing classified ad (HELP WANTED:
    Methane Manufacturer; Must Be Willing to Work Indoors), there does not
    seem to be any way to increase the population of the desired microbe.

    It's only in recent years that we've identified all the bacteria in the
    intestines, Levitt says. It will be a while before we can effectively
    manipulate them.

    On other fronts Levitt has had greater success, most recently developing
    a simple Breathalyzer test that can check a patient for incipient
    flatulence. To the average nongastroenterologist this seems a bit
    counterintuitive, and if Levitt is checking his patients' breath for
    flatulence, I wouldn't even ask how he'd propose to conduct dental work.
    Levitt, however, insists his system works, explaining that what goes on
    at one end of the alimentary autobahn can often reveal a lot about
    what's happening at the other.

    Flatulence is characterized by an overproduction of a wide range of
    gases, including hydrogen, he says. Not all of the gas generated in the
    intestines is excreted, however; some of it is absorbed by the blood and
    exhaled through the lungs. If you can measure the level of excess
    hydrogen in a patient's breath, therefore, you can diagnose a flatulence
    problem and perhaps help reverse it.

    In a world that has long lionized doctors, Levitt knows that he will
    forever labor in something close to obscurity. There will be no prime-
    time programs dramatizing flatulence work (St. Anywhere Elsewhere), no
    CNN panel shows debating it (Crossfire!), no PBS specials helping raise
    money for it (All Creatures Great and Small--But Some From a Distance).
    Nevertheless, Levitt remains committed to his discipline of choice, and
    well he might. It was no less a physician than Hippocrates who coined
    the admonition First, do no harm. Levitt can take some satisfaction in
    knowing that his medical specialty is the only one in which this rule
    applies as much to the patient as it does to the doctor.
    Do you want me to go fart-her?
    Brian (the devil incarnate)

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